Incretin-related and amylin peptides
Mazdutide
Mazdutide (IBI362, LY3305677) is a synthetic peptide analogue of oxyntomodulin that acts on both the GLP-1 receptor and the glucagon receptor.
- TypePeptide
- FormulaC207H317N45O65
- Average mass4475.99 g/mol
- CAS2259884-03-0
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Mazdutide at a glance
Oxyntomodulin is a natural gut peptide that activates the GLP-1 and glucagon receptors. Mazdutide is an engineered analogue designed to give balanced dual activity, and its pharmacology is described in recent preclinical papers.
It is used in research on dual GLP-1/glucagon receptor signalling and related metabolic models, and is supplied as a research material only.
Structure
PubChem lists the molecule as a modified peptide of about 4.5 kDa. As with other engineered incretin analogues it contains non-standard components, so its mass is best confirmed on the intact molecule.
Identity
Identity data
| Name | Mazdutide |
|---|---|
| Also written as | IBI362, LY3305677 |
| Type | Peptide |
| Research area | Incretin-related and amylin peptides |
| Molecular formula | C207H317N45O65 |
| Monoisotopic mass | 4473.2883 Da |
| Average molecular weight | 4475.99 g/mol |
| CAS number | 2259884-03-0 |
| PubChem record | CID 167312357 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 4473.2883 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 4476.0 Da instead.
| Ion | m/z |
|---|---|
| [M+3H]3+ | 1492.1034 |
| [M+4H]4+ | 1119.3294 |
| [M+5H]5+ | 895.6649 |
| [M+6H]6+ | 746.5553 |
For molecules of this size the tallest isotope peak is one to two mass units above the monoisotopic peak. Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Check that the COA gives an intact-mass result and that the main HPLC peak is integrated with a stated method.
- Do not rely on a sequence-only calculation for the expected mass.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Vesta listings
Mazdutide formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Mazdutide | 5 mg | MZ5 | $205.22 | $20.52 |
| Mazdutide | 10 mg | MZ10 | $376.87 | $37.69 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- The GLP-1R/GCGR Dual Agonist Mazdutide Attenuates Liver Steatosis and Decreases Circulating Cholesterol Levels in Mice With Metabolic Dysfunction-Associated Steatotic Liver DiseaseYu L, Wang G, Zhang J et al. · Diabetes Obes Metab · 2026 · PMID 42875732
- Mazdutide Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Endoplasmic Reticulum Stress, Improving Lipid Metabolism and Alleviating InflammationGan L, Duan L, Zheng X et al. · Pharmaceuticals (Basel) · 2026 · PMID 41901218
Questions
Frequently asked questions
What is Mazdutide?
Mazdutide (IBI362, LY3305677) is a synthetic peptide analogue of oxyntomodulin that acts on both the GLP-1 receptor and the glucagon receptor.
What is the molecular weight of Mazdutide?
Mazdutide has the formula C207H317N45O65, an average molecular weight of 4475.99 g/mol and a monoisotopic mass of 4473.2883 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Mazdutide?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+4H]4+ at m/z 1119.3294. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Mazdutide products does Vesta list?
Vesta lists 2 products for Mazdutide: 5 mg, 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.