Incretin-related and amylin peptides
Tirzepatide
Tirzepatide is a synthetic 39-residue peptide based on the sequence of glucose-dependent insulinotropic polypeptide (GIP) that acts as an agonist at both the GIP receptor and the GLP-1 receptor.
- TypePeptide
- FormulaC225H348N48O68
- Average mass4813.45 g/mol
- CAS2023788-19-2
- Vesta listings12
Reference page for laboratory use · updated 2026-10-30
Overview
Tirzepatide at a glance
It is described in the literature as a dual GIP and GLP-1 receptor agonist, and its receptor pharmacology (including its biased and imbalanced signalling profile) is the subject of published in-vitro work.
In research, it is used to study incretin receptor signalling, receptor selectivity and dual-agonist design. It is supplied here strictly as a research material.
Structure
The peptide contains two α-aminoisobutyric acid residues, a C-terminal amide, and a C20 fatty diacid attached to a lysine side chain through a linker, which extends albumin binding.
Identity
Identity data
| Name | Tirzepatide |
|---|---|
| Also written as | LY3298176 |
| Type | Peptide |
| Research area | Incretin-related and amylin peptides |
| Molecular formula | C225H348N48O68 |
| Monoisotopic mass | 4810.5249 Da |
| Average molecular weight | 4813.45 g/mol |
| CAS number | 2023788-19-2 |
| PubChem record | CID 166567236 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 4810.5249 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 4813.4 Da instead.
| Ion | m/z |
|---|---|
| [M+3H]3+ | 1604.5156 |
| [M+4H]4+ | 1203.6385 |
| [M+5H]5+ | 963.1123 |
| [M+6H]6+ | 802.7614 |
For molecules of this size the tallest isotope peak is one to two mass units above the monoisotopic peak. Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Tirzepatide is a modified peptide, so its mass should be confirmed from the intact molecule; a mass calculated only from the amino acid letters will not match.
- Expect a multiply charged ion series in electrospray mass spectrometry and a deconvoluted mass close to the value in the table above.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide, Mass spectrometry.
Vesta listings
Tirzepatide formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Tirzepatide | 5 mg | TR5 | $31.72 | $3.17 |
| Tirzepatide | 10 mg | TR10 | $46.64 | $4.66 |
| Tirzepatide | 15 mg | TR15 | $61.57 | $6.16 |
| Tirzepatide | 20 mg | TR20 | $82.09 | $8.21 |
| Tirzepatide | 30 mg | TR30 | $111.94 | $11.19 |
| Tirzepatide | 40 mg | TR40 | $134.33 | $13.43 |
| Tirzepatide | 50 mg | TR50 | $171.64 | $17.16 |
| Tirzepatide | 60 mg | TR60 | $197.76 | $19.78 |
| Tirzepatide | 80 mg | TR80 | $250.00 | $25.00 |
| Tirzepatide | 100 mg | TR100 | $298.51 | $29.85 |
| Tirzepatide | 120 mg | TR120 | $354.48 | $35.45 |
Research blends that contain Tirzepatide
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Retatrutide+Tirzepatide | 60 mg | RET60 | $305.97 | $30.60 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonistWillard FS, Douros JD, Gabe MB et al. · JCI Insight · 2020 · PMID 32730231
- Tirzepatide: A Systematic UpdateForzano I, Varzideh F, Avvisato R et al. · Int J Mol Sci · 2022 · PMID 36498958
Questions
Frequently asked questions
What is Tirzepatide?
Tirzepatide is a synthetic 39-residue peptide based on the sequence of glucose-dependent insulinotropic polypeptide (GIP) that acts as an agonist at both the GIP receptor and the GLP-1 receptor.
What is the molecular weight of Tirzepatide?
Tirzepatide has the formula C225H348N48O68, an average molecular weight of 4813.45 g/mol and a monoisotopic mass of 4810.5249 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Tirzepatide?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+4H]4+ at m/z 1203.6385. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Tirzepatide products does Vesta list?
Vesta lists 12 products for Tirzepatide: 5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 50 mg, 60 mg, 80 mg, 100 mg, 120 mg per vial in kits of 10 vials, plus 1 research blend that contain it. Prices are shown per kit in US dollars, and shipping is paid by the customer.