Incretin-related and amylin peptides
Survodutide
Survodutide (BI 456906) is a synthetic peptide that acts as a dual agonist of the glucagon receptor and the GLP-1 receptor.
- TypePeptide
- FormulaC192H289N47O61
- Average mass4231.63 g/mol
- CAS2805997-46-8
- Vesta listings1
Reference page for laboratory use · updated 2026-10-30
Overview
Survodutide at a glance
It was developed as a balanced glucagon/GLP-1 dual agonist, and its pharmacological profiling and central nervous system targets are described in published preclinical studies.
Researchers use it to compare glucagon receptor activity with GLP-1 receptor activity in cell and animal models. It is provided here as a research material.
Structure
PubChem gives a molecular formula of C192H289N47O61 for the compound. It is a modified peptide, so non-standard residues or side chains are part of the structure.
Identity
Identity data
| Name | Survodutide |
|---|---|
| Also written as | BI 456906 |
| Type | Peptide |
| Research area | Incretin-related and amylin peptides |
| Molecular formula | C192H289N47O61 |
| Monoisotopic mass | 4229.0957 Da |
| Average molecular weight | 4231.63 g/mol |
| CAS number | 2805997-46-8 |
| PubChem record | CID 171378821 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 4229.0957 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 4231.6 Da instead.
| Ion | m/z |
|---|---|
| [M+3H]3+ | 1410.7058 |
| [M+4H]4+ | 1058.2812 |
| [M+5H]5+ | 846.8264 |
| [M+6H]6+ | 705.8566 |
For molecules of this size the tallest isotope peak is one to two mass units above the monoisotopic peak. Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Confirm identity by intact mass rather than by sequence letters alone.
- Ask for the chromatogram and the integration parameters, not only a purity percentage.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide.
Vesta listings
Survodutide formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Survodutide | 10 mg | SUR10 | $291.04 | $29.10 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- The dual GCGR/GLP-1R agonist survodutide: Biomarkers and pharmacological profiling for clinical candidate selectionThomas L, Martel E, Rist W et al. · Diabetes Obes Metab · 2024 · PMID 38560764
- Survodutide acts through circumventricular organs in the brain and activates neuronal regions associated with appetite regulationZimmermann T, Bleymehl K, Haebel P et al. · Mol Metab · 2026 · PMID 41638399
Questions
Frequently asked questions
What is Survodutide?
Survodutide (BI 456906) is a synthetic peptide that acts as a dual agonist of the glucagon receptor and the GLP-1 receptor.
What is the molecular weight of Survodutide?
Survodutide has the formula C192H289N47O61, an average molecular weight of 4231.63 g/mol and a monoisotopic mass of 4229.0957 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Survodutide?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+4H]4+ at m/z 1058.2812. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Survodutide products does Vesta list?
Vesta lists 1 product for Survodutide: 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.