Research area
Mitochondria-related peptides are either designed to accumulate in mitochondria (SS-31) or encoded by the mitochondrial genome (MOTS-c).
SS-31 (elamipretide) is a tetrapeptide with alternating aromatic and cationic residues that interacts with cardiolipin in the inner mitochondrial membrane. MOTS-c is a 16-residue peptide encoded by the mitochondrial 12S rRNA gene, one of the mitochondrial-derived peptides.
Researchers use them in studies of mitochondrial function, mitochondria-to-nucleus signalling and metabolic stress in cells and animals.
Oxidation, deamidation, disulfide changes, pyroglutamate formation and adducts each leave a characteristic mass difference. Learn the numbers and…
GuideMass Spectrometry for Peptide Identity: A Practical GuideHow expected mass, observed ions, charge states, adducts, and deconvolution support peptide identity without being confused with purity.
ExplainerPeptide Purity vs Vial Content: Why the Numbers DifferWhy a high HPLC area percentage does not establish peptide quantity, net vial mass, identity, water content, or counterion content.
MOTS-c, SS-31.
MOTS-c has two methionines; mono- and di-oxidised variants appear at +15.995 Da and +31.990 Da. SS-31 contains a D-arginine and a dimethyltyrosine; neither changes the interpretation of the mass spectrum, but both mean that the sequence cannot be written with standard letters alone.
Incretin-related and amylin peptides · Growth hormone axis peptides · Copper peptides · Short regulatory and thymic peptides · Host-defence and tissue-repair peptides · Neuropeptide-derived peptides · Melanocortin peptides · Metabolites and small molecules · Multi-component research blends
