Incretin-related and amylin peptides
Cagrilintide
Cagrilintide is a long-acting synthetic analogue of the pancreatic hormone amylin that acts on amylin and calcitonin receptors.
- TypePeptide
- FormulaC194H312N54O59S2
- Average mass4409.01 g/mol
- CAS1415456-99-3
- Vesta listings7
Reference page for laboratory use · updated 2026-10-30
Overview
Cagrilintide at a glance
Native amylin is a 37-residue hormone co-secreted with insulin. Cagrilintide was engineered with sequence changes and a fatty diacid side chain, and its development is described in the Journal of Medicinal Chemistry.
Structural studies of cagrilintide bound to amylin and calcitonin receptors are published, which makes it useful as a reference ligand for these receptor systems. It is supplied here as a research material.
Structure
PubChem lists the molecule with two sulfur atoms, consistent with the disulfide bridge found in amylin-type peptides, plus the acylated side chain.
Identity
Identity data
| Name | Cagrilintide |
|---|---|
| Also written as | NN9838 |
| Type | Peptide |
| Research area | Incretin-related and amylin peptides |
| Molecular formula | C194H312N54O59S2 |
| Monoisotopic mass | 4406.2515 Da |
| Average molecular weight | 4409.01 g/mol |
| CAS number | 1415456-99-3 |
| PubChem record | CID 171397054 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 4406.2515 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 4409.0 Da instead.
| Ion | m/z |
|---|---|
| [M+3H]3+ | 1469.7578 |
| [M+4H]4+ | 1102.5702 |
| [M+5H]5+ | 882.2576 |
| [M+6H]6+ | 735.3825 |
For molecules of this size the tallest isotope peak is one to two mass units above the monoisotopic peak. Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Disulfide-containing peptides can show a reduced form that is 2.016 Da heavier than the intact molecule; the COA should show that this form is absent or minor.
- Vesta also lists research blends that contain cagrilintide together with semaglutide or tirzepatide.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Disulfide bond.
Vesta listings
Cagrilintide formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Cagrilintide | 5 mg | CGL5 | $113.81 | $11.38 |
| Cagrilintide | 10 mg | CGL10 | $197.76 | $19.78 |
Research blends that contain Cagrilintide
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Cagri+Semaglutide | 5 mg | CS5 | $111.94 | $11.19 |
| Cagri+Semaglutide | 10 mg | CS10 | $158.58 | $15.86 |
| Cagri+Tirzepatide | 10 mg | TRC10 | $160.45 | $16.04 |
| Cagri+Semaglutide | 20 mg | CS20 | $257.46 | $25.75 |
| Cagri+Tirzepatide | 20 mg | TRC20 | $263.06 | $26.31 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Development of Cagrilintide, a Long-Acting Amylin AnalogueKruse T, Hansen JL, Dahl K et al. · J Med Chem · 2021 · PMID 34288673
- Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptorsCao J, Belousoff MJ, Johnson RM et al. · Nat Commun · 2025 · PMID 40204768
- Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Carvas AO, Leuthardt A, Kulka P et al. · EBioMedicine · 2025 · PMID 40609154
Questions
Frequently asked questions
What is Cagrilintide?
Cagrilintide is a long-acting synthetic analogue of the pancreatic hormone amylin that acts on amylin and calcitonin receptors.
What is the molecular weight of Cagrilintide?
Cagrilintide has the formula C194H312N54O59S2, an average molecular weight of 4409.01 g/mol and a monoisotopic mass of 4406.2515 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Cagrilintide?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+4H]4+ at m/z 1102.5702. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Cagrilintide products does Vesta list?
Vesta lists 7 products for Cagrilintide: 5 mg, 10 mg per vial in kits of 10 vials, plus 5 research blends that contain it. Prices are shown per kit in US dollars, and shipping is paid by the customer.