Tesamorelin
Tesamorelin is a synthetic 44-residue analogue of human GHRH (1-44) in which the N-terminus carries a trans-3-hexenoyl group.
- TypePeptide
- FormulaC221H366N72O67S
- Average mass5135.78 g/mol
- CAS218949-48-5
- Vesta listings4
Reference page for laboratory use · updated 2026-10-30
Overview
Tesamorelin at a glance
Tesamorelin keeps the full GHRH sequence and adds an N-terminal hexenoyl modification that changes its stability against enzymatic cleavage. Its chemistry and pharmacology are covered in drug-profile literature.
Analytical chemistry groups have also published LC-MS/MS methods for detecting GHRH analogues, which are useful references for batch identity testing.
Structure
Because of the N-terminal hexenoyl group and 44 residues, the molecule has a mass of more than 5 kDa and is usually observed as a series of multiply charged ions.
Identity
Identity data
| Name | Tesamorelin |
|---|---|
| Also written as | TH9507 |
| Type | Peptide |
| Research area | Growth hormone axis peptides |
| Molecular formula | C221H366N72O67S |
| Monoisotopic mass | 5132.7166 Da |
| Average molecular weight | 5135.78 g/mol |
| CAS number | 218949-48-5, 804475-66-9 |
| PubChem record | CID 16137828 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 5132.7166 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 5135.8 Da instead.
| Ion | m/z |
|---|---|
| [M+3H]3+ | 1711.9128 |
| [M+4H]4+ | 1284.1864 |
| [M+5H]5+ | 1027.5506 |
| [M+6H]6+ | 856.4600 |
For molecules of this size the tallest isotope peak is one to two mass units above the monoisotopic peak. Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Like other GHRH-type peptides it contains methionine, so a +15.995 Da oxidised variant is the first impurity to look for.
- The Vesta listing also includes a blend of tesamorelin with ipamorelin.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Vesta listings
Tesamorelin formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Tesamorelin | 5 mg | TSM5 | $115.67 | $11.57 |
| Tesamorelin | 10 mg | TSM10 | $197.76 | $19.78 |
| Tesamorelin | 20 mg | TSM20 | $363.81 | $36.38 |
Research blends that contain Tesamorelin
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Tesamorelin10mg+Ipamorelin5mg | 15 mg | TI | $253.73 | $25.37 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- TesamorelinGrunfeld C, Dritselis A, Kirkpatrick P et al. · Nat Rev Drug Discov · 2011 · PMID 21283099
- Advances in the detection of growth hormone releasing hormone synthetic analogsMemdouh S, Gavrilović I, Ng K et al. · Drug Test Anal · 2021 · PMID 34665524
- Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samplesCristea CD, Radu M, Toboc A et al. · Anal Biochem · 2023 · PMID 37806509
Questions
Frequently asked questions
What is Tesamorelin?
Tesamorelin is a synthetic 44-residue analogue of human GHRH (1-44) in which the N-terminus carries a trans-3-hexenoyl group.
What is the molecular weight of Tesamorelin?
Tesamorelin has the formula C221H366N72O67S, an average molecular weight of 5135.78 g/mol and a monoisotopic mass of 5132.7166 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Tesamorelin?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+4H]4+ at m/z 1284.1864. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Tesamorelin products does Vesta list?
Vesta lists 4 products for Tesamorelin: 5 mg, 10 mg, 20 mg per vial in kits of 10 vials, plus 1 research blend that contain it. Prices are shown per kit in US dollars, and shipping is paid by the customer.