Ipamorelin
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) that acts as an agonist of the ghrelin receptor, also called the growth hormone secretagogue receptor.
- TypePeptide
- FormulaC38H49N9O5
- Average mass711.85 g/mol
- CAS170851-70-4
- Vesta listings5
Reference page for laboratory use · updated 2026-10-30
Overview
Ipamorelin at a glance
It was described in 1998 as the first selective growth hormone secretagogue, and later papers cover its pharmacokinetics and the design of related hybrid compounds.
Researchers use it as a selective ghrelin-receptor agonist in receptor-binding and signalling studies.
Structure
It contains two D-amino acids, a non-natural amino acid (D-2-naphthylalanine), an α-aminoisobutyric acid residue and a C-terminal amide. The sequence-based formula matches the PubChem record exactly.
Identity
Identity data
| Name | Ipamorelin |
|---|---|
| Also written as | NNC 26-0161 |
| Type | Peptide |
| Research area | Growth hormone axis peptides |
| Molecular formula | C38H49N9O5 |
| Monoisotopic mass | 711.3857 Da |
| Average molecular weight | 711.85 g/mol |
| CAS number | 170851-70-4 |
| Sequence | Aib-His-2Nal-Phe-Lys-NH2 |
| PubChem record | CID 9831659 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 711.3857 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 711.9 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 712.3930 |
| [M+2H]2+ | 356.7001 |
| [M+Na]+ | 734.3749 |
| [M+K]+ | 750.3489 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- With a mass near 712 Da it is usually seen as a singly charged ion, [M+H]+ at m/z 712.39.
- D-amino acids have the same mass as L-amino acids, so epimerised impurities need chiral or high-resolution chromatographic methods.
- No residue in this sequence is especially prone to oxidation or deamidation, so most extra peaks are likely to be synthesis-related impurities or adducts.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: D-amino acid.
Vesta listings
Ipamorelin formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Ipamorelin | 5 mg | IP5 | $63.43 | $6.34 |
| Ipamorelin | 10 mg | IP10 | $89.55 | $8.96 |
Research blends that contain Ipamorelin
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| CJC1295+Ipamorelin | 10 mg | CP10 | $141.79 | $14.18 |
| Tesamorelin10mg+Ipamorelin5mg | 15 mg | TI | $253.73 | $25.37 |
| CJC1295+Ipamorelin | 20 mg | CP20 | $263.06 | $26.31 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Ipamorelin, the first selective growth hormone secretagogueRaun K, Hansen BS, Johansen NL et al. · Eur J Endocrinol · 1998 · PMID 9849822
- Pharmacokinetic evaluation of ipamorelin and other peptidyl growth hormone secretagogues with emphasis on nasal absorptionJohansen PB, Hansen KT, Andersen JV et al. · Xenobiotica · 1998 · PMID 9879640
- Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelinHansen TK, Ankersen M, Raun K et al. · Bioorg Med Chem Lett · 2001 · PMID 11459660
Questions
Frequently asked questions
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) that acts as an agonist of the ghrelin receptor, also called the growth hormone secretagogue receptor.
What is the molecular weight of Ipamorelin?
Ipamorelin has the formula C38H49N9O5, an average molecular weight of 711.85 g/mol and a monoisotopic mass of 711.3857 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Ipamorelin?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 356.7001. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Ipamorelin products does Vesta list?
Vesta lists 5 products for Ipamorelin: 5 mg, 10 mg per vial in kits of 10 vials, plus 3 research blends that contain it. Prices are shown per kit in US dollars, and shipping is paid by the customer.