Host-defence and tissue-repair peptides
ARA290
ARA290 (cibinetide, pHBSP) is an 11-residue peptide derived from the helix B surface of erythropoietin and described in the literature as lacking erythropoietic activity.
- TypePeptide
- FormulaC51H84N16O21
- Average mass1257.31 g/mol
- CAS1208243-50-8
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
ARA290 at a glance
The sequence is pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. It was designed to interact with the innate repair receptor, a heteromer of the erythropoietin receptor and the β-common receptor, and papers describe its effects on innate immune cells.
Note that one paper on the related pHBSP peptide has been retracted; always read the primary data.
Structure
The N-terminus is a pyroglutamate. The calculated formula matches PubChem exactly.
Identity
Identity data
| Name | ARA290 |
|---|---|
| Also written as | Cibinetide, pHBSP |
| Type | Peptide |
| Research area | Host-defence and tissue-repair peptides |
| Molecular formula | C51H84N16O21 |
| Monoisotopic mass | 1256.5997 Da |
| Average molecular weight | 1257.31 g/mol |
| CAS number | 1208243-50-8 |
| Sequence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| PubChem record | CID 91810664 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 1256.5997 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 1257.3 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 1257.6070 |
| [M+2H]2+ | 629.3071 |
| [M+Na]+ | 1279.5889 |
| [M+K]+ | 1295.5629 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- The pyroglutamate N-terminus has no free amine, which affects both ion formation and Edman sequencing.
- Acidic residues (Glu) make the peptide polar; use an HPLC gradient that starts at low organic solvent.
- Mass shifts to look for in this sequence: deamidation of Asn or Gln (+0.984 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide, N-terminus, Pyroglutamate, HPLC.
Vesta listings
ARA290 formats and prices
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- The erythropoietin analogue ARA290 modulates the innate immune response and reduces Escherichia coli invasion into urothelial cellsPolgárová K, Lüthje P, Cerami A et al. · FEMS Immunol Med Microbiol · 2011 · PMID 21410562
- Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitisNairz M, Haschka D, Dichtl S et al. · Sci Rep · 2017 · PMID 29026145
Questions
Frequently asked questions
What is ARA290?
ARA290 (cibinetide, pHBSP) is an 11-residue peptide derived from the helix B surface of erythropoietin and described in the literature as lacking erythropoietic activity.
What is the molecular weight of ARA290?
ARA290 has the formula C51H84N16O21, an average molecular weight of 1257.31 g/mol and a monoisotopic mass of 1256.5997 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of ARA290?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 629.3071. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which ARA290 products does Vesta list?
Vesta lists 2 products for ARA290: 10 mg, 16 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.