Host-defence and tissue-repair peptides
KPV
KPV is the tripeptide Lys-Pro-Val, which corresponds to the C-terminal residues 11-13 of α-melanocyte-stimulating hormone.
- TypePeptide
- FormulaC16H30N4O4
- Average mass342.43 g/mol
- CAS67727-97-3
- Vesta listings3
Reference page for laboratory use · updated 2026-10-30
Overview
KPV at a glance
Studies of α-MSH fragments showed that the C-terminal tripeptide retained anti-inflammatory activity in cell models. A stability-indicating HPLC assay for KPV has been published, which makes KPV a good example of a small peptide that can be assayed precisely.
Delivery research on KPV covers topical and nano-carrier formulations.
Structure
The molecule has three residues and no modification; the calculated formula matches PubChem exactly.
Identity
Identity data
| Name | KPV |
|---|---|
| Also written as | α-MSH(11-13), Lys-Pro-Val |
| Type | Peptide |
| Research area | Host-defence and tissue-repair peptides |
| Molecular formula | C16H30N4O4 |
| Monoisotopic mass | 342.2267 Da |
| Average molecular weight | 342.43 g/mol |
| CAS number | 67727-97-3 |
| Sequence | Lys-Pro-Val |
| PubChem record | CID 125672 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 342.2267 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 342.4 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 343.2340 |
| [M+Na]+ | 365.2159 |
| [M+K]+ | 381.1899 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- At 342.4 Da, [M+H]+ is m/z 343.23, and [M+Na]+ at m/z 365.22 is common.
- A stability-indicating method resolves KPV from its degradation products; ask which HPLC method was used.
- No residue in this sequence is especially prone to oxidation or deamidation, so most extra peaks are likely to be synthesis-related impurities or adducts.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: HPLC, Peptide, Stability-indicating method.
Vesta listings
KPV formats and prices
Research blends that contain KPV
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Klow | 80 mg | Klow80 | $253.73 | $25.37 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptidesGetting SJ, Schiöth HB, Perretti M et al. · J Pharmacol Exp Ther · 2003 · PMID 12750433
- Stability-indicating HPLC assay for lysine-proline-valine (KPV) in aqueous solutions and skin homogenatesPawar KR, Mulabagal V, Smith F et al. · Biomed Chromatogr · 2015 · PMID 25298219
Questions
Frequently asked questions
What is KPV?
KPV is the tripeptide Lys-Pro-Val, which corresponds to the C-terminal residues 11-13 of α-melanocyte-stimulating hormone.
What is the molecular weight of KPV?
KPV has the formula C16H30N4O4, an average molecular weight of 342.43 g/mol and a monoisotopic mass of 342.2267 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of KPV?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+Na]+ at m/z 365.2159. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which KPV products does Vesta list?
Vesta lists 3 products for KPV: 5 mg, 10 mg per vial in kits of 10 vials, plus 1 research blend that contain it. Prices are shown per kit in US dollars, and shipping is paid by the customer.