Gonadorelin
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH, LHRH), a decapeptide with the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.
- TypePeptide
- FormulaC55H75N17O13
- Average mass1182.29 g/mol
- CAS33515-09-2
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Gonadorelin at a glance
GnRH is released from the hypothalamus and acts on the GnRH receptor of pituitary cells. The structure and function of the receptor, and the analytical techniques used to measure small peptide hormones such as gonadorelin, are covered by recent reviews.
In research it is used as the native-sequence reference agonist.
Structure
The N-terminus is a cyclic pyroglutamate and the C-terminus is an amide, so neither end has a free charge. The calculated formula matches PubChem exactly.
Identity
Identity data
| Name | Gonadorelin |
|---|---|
| Also written as | GnRH, LHRH |
| Type | Peptide |
| Research area | Neuropeptide-derived peptides |
| Molecular formula | C55H75N17O13 |
| Monoisotopic mass | 1181.5730 Da |
| Average molecular weight | 1182.29 g/mol |
| CAS number | 33515-09-2 |
| Sequence | pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 |
| PubChem record | CID 638793 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 1181.5730 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 1182.3 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 1182.5803 |
| [M+2H]2+ | 591.7938 |
| [M+Na]+ | 1204.5622 |
| [M+K]+ | 1220.5362 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Pyroglutamate formation from glutamine is a common artefact in synthetic peptides; ensure the COA mass matches the pyroglutamate form.
- Gonadorelin is often supplied as an acetate or hydrochloride, which changes the molecular weight on the COA.
- Mass shifts to look for in this sequence: tryptophan oxidation (+15.995 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide, N-terminus, Pyroglutamate, C-terminus.
Vesta listings
Gonadorelin formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Gonadorelin | 2 mg | GND2 | $48.51 | $4.85 |
| Gonadorelin | 5 mg | GND5 | $78.36 | $7.84 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Advances and perspectives in the analytical technology for small peptide hormones analysis: A glimpse to gonadorelinTorrini F, Scarano S, Palladino P et al. · J Pharm Biomed Anal · 2023 · PMID 36858006
- Gonadotropin-Releasing Hormone and GnRH Receptor: Structure, Function and Drug DevelopmentTzoupis H, Nteli A, Androutsou ME et al. · Curr Med Chem · 2020 · PMID 31309882
Questions
Frequently asked questions
What is Gonadorelin?
Gonadorelin is the synthetic form of gonadotropin-releasing hormone (GnRH, LHRH), a decapeptide with the sequence pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2.
What is the molecular weight of Gonadorelin?
Gonadorelin has the formula C55H75N17O13, an average molecular weight of 1182.29 g/mol and a monoisotopic mass of 1181.5730 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Gonadorelin?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 591.7938. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Gonadorelin products does Vesta list?
Vesta lists 2 products for Gonadorelin: 2 mg, 5 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.