Dihexa
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic peptide-like analogue of angiotensin IV that has been described as acting through the hepatocyte growth factor (HGF)/c-Met system.
- TypePeptide
- FormulaC27H44N4O5
- Average mass504.66 g/mol
- CAS1401708-83-5
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Dihexa at a glance
Dihexa was derived from the angiotensin IV peptide family. A pharmacology paper on angiotensin IV-derived peptides shows that their effects depend on activation of the HGF/c-Met pathway, and later studies use it in mouse models of cognition.
It is a small peptide-like molecule of about 505 Da, with chemistry that is closer to a modified dipeptide than a classical peptide.
Structure
The molecule is a hexanoyl-capped tyrosine-isoleucine unit linked to an aminohexanoic amide. PubChem gives the formula C27H44N4O5.
Identity
Identity data
| Name | Dihexa |
|---|---|
| Also written as | PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide |
| Type | Peptide |
| Research area | Neuropeptide-derived peptides |
| Molecular formula | C27H44N4O5 |
| Monoisotopic mass | 504.3312 Da |
| Average molecular weight | 504.66 g/mol |
| CAS number | 1401708-83-5 |
| PubChem record | CID 129010512 |
The formula comes from the PubChem record; monoisotopic mass is calculated from the formula and the average mass uses standard atomic weights. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 504.3312 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 504.7 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 505.3385 |
| [M+2H]2+ | 253.1729 |
| [M+Na]+ | 527.3204 |
| [M+K]+ | 543.2944 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- At about 505 Da it ionises as [M+H]+ at m/z 505.34; ask for the mass spectrum and an HPLC chromatogram.
- Because it is not a standard peptide, no sequence-based calculation is shown here.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Vesta listings
Dihexa formats and prices
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met systemBenoist CC, Kawas LH, Zhu M et al. · J Pharmacol Exp Ther · 2014 · PMID 25187433
- AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling PathwaySun X, Deng Y, Fu X et al. · Brain Sci · 2021 · PMID 34827486
Questions
Frequently asked questions
What is Dihexa?
Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic peptide-like analogue of angiotensin IV that has been described as acting through the hepatocyte growth factor (HGF)/c-Met system.
What is the molecular weight of Dihexa?
Dihexa has the formula C27H44N4O5, an average molecular weight of 504.66 g/mol and a monoisotopic mass of 504.3312 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Dihexa?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 253.1729. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Dihexa products does Vesta list?
Vesta lists 2 products for Dihexa: 5 mg, 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.