AOD9604
AOD9604 is a synthetic 16-residue peptide made of the C-terminal fragment 177-191 of human growth hormone with an extra N-terminal tyrosine, closed by a disulfide bond.
- TypePeptide
- FormulaC78H123N23O23S2
- Average mass1815.08 g/mol
- CAS221231-10-3
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
AOD9604 at a glance
The fragment was studied because it contains the region of growth hormone associated with lipid metabolism in early research, without the full hormone. Reviews and analytical papers describe its profile.
Analytical groups have published methods for its detection and its in-vitro metabolism, which are a good reference when verifying identity.
Structure
The sequence is YLRIVQCRSVEGSCGF with a Cys7-Cys14 disulfide bond. The calculated formula from the sequence matches PubChem exactly.
Identity
Identity data
| Name | AOD9604 |
|---|---|
| Also written as | Tyr-hGH 177-191, AOD-9604 |
| Type | Peptide |
| Research area | Growth hormone axis peptides |
| Molecular formula | C78H123N23O23S2 |
| Monoisotopic mass | 1813.8604 Da |
| Average molecular weight | 1815.08 g/mol |
| CAS number | 221231-10-3 |
| Sequence | YLRIVQCRSVEGSCGF |
| Ring structure | Cyclic: disulfide bond between two cysteines |
| PubChem record | CID 71300630 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 1813.8604 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 1815.1 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 1814.8677 |
| [M+2H]2+ | 907.9375 |
| [M+3H]3+ | 605.6274 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- The reduced (open) form is 2.016 Da heavier than the oxidised disulfide form in the table.
- Cysteine-containing peptides can form dimers on storage; look for a peak at about twice the mass.
- Mass shifts to look for in this sequence: deamidation of Asn or Gln (+0.984 Da); a reduced disulfide (+2.016 Da).
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Disulfide bond.
Vesta listings
AOD9604 formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| AOD9604 | 5 mg | 5AD | $145.52 | $14.55 |
| AOD9604 | 10 mg | 10AD | $259.33 | $25.93 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- AOD-9604 MetabolicWilding J · Curr Opin Investig Drugs · 2004 · PMID 15134286
- Detection and in vitro metabolism of AOD9604Cox HD, Smeal SJ, Hughes CM et al. · Drug Test Anal · 2015 · PMID 25208511
- Identification and characterization of peptide drugs in unknown pharmaceutical preparations seized by the Belgian authorities: case report on AOD9604Vanhee C, Moens G, Deconinck E et al. · Drug Test Anal · 2014 · PMID 24976118
Questions
Frequently asked questions
What is AOD9604?
AOD9604 is a synthetic 16-residue peptide made of the C-terminal fragment 177-191 of human growth hormone with an extra N-terminal tyrosine, closed by a disulfide bond.
What is the molecular weight of AOD9604?
AOD9604 has the formula C78H123N23O23S2, an average molecular weight of 1815.08 g/mol and a monoisotopic mass of 1813.8604 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of AOD9604?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+2H]2+ at m/z 907.9375. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which AOD9604 products does Vesta list?
Vesta lists 2 products for AOD9604: 5 mg, 10 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.