Short answer

A receiving inspection should confirm that the shipment, labels, batch documentation, container count, seals, and visible condition agree with the order before material is released to inventory. Record the condition on arrival, photograph labels and packaging, link the batch to its COA, and quarantine any discrepancy for supplier review.

Key facts

  • Receiving inspection confirms that what arrived matches what was ordered and documented.
  • Record the condition on arrival with photographs before anything is opened or moved.
  • Link each container to its batch and its certificate of analysis.
  • Quarantine any discrepancy and tell the supplier in writing.
  • Release to inventory is a decision with a name and a date.

Why inspect on arrival

A receiving inspection is the first point at which a laboratory can catch a problem and the last point at which the evidence is still intact. It confirms that the shipment, labels, batch documentation, container count, seals and visible condition agree with the order before material is released to inventory. It also fixes the time and condition of receipt, which matters if there is later a dispute about transport.

Before the parcel is opened

Photograph the outer packaging, the shipping label and any seals or tape. Note the date and time, the carrier and the tracking number, and whether the parcel is intact, wet or damaged. Record any temperature indicator if one was included. Do not discard packaging until the inspection is closed, because it may be needed for a carrier claim.

Check the contents against the paperwork

Open the parcel in a clean area and compare the contents with the packing list and the order.

  • Product names and SKUs
  • Quantity of vials and kits
  • Batch or lot codes on each container
  • Seals, caps and crimps intact
  • Label legibility and agreement with the packing list
  • Any documents enclosed, such as certificates of analysis

Look at the material

Inspect each vial for the state of the lyophilized cake. A cake is normally a white or off-white, porous solid. Collapse, discolouration, wet patches or loose powder in the cap suggest moisture or an excursion in transit and should be recorded. Do not open sealed vials for this check; view them through the glass and photograph them.

Copper-containing peptides are blue in colour, and some small molecules are coloured or are supplied as liquids, so compare with the product documentation.

Decide and record

Record the disposition: accept, accept with comment or quarantine. Sign and date the entry, and store it with the batch file. A quarantine entry should state the discrepancy, the photographs taken and the person informed. Quarantined material should be physically separated from released stock and labelled so that no one uses it by mistake.

Store immediately

Move accepted material to its documented storage condition without delay and record the time. Lyophilized peptides are normally kept cold and dry, but the product documentation governs. The guide to documenting storage conditions describes what to record.

Frequently asked questions

Should vials be opened during receiving inspection?

No. Inspect through the glass and keep the seal intact. Opening a vial exposes the material to moisture and creates a record problem.

What if the parcel arrived warm?

Record the condition, photograph the packaging and any indicator, and quarantine the material until the supplier's documentation supports a decision. Do not assume that a warm parcel means damaged material; ask for the stability information.

How should discrepancies be reported?

In writing, with the order number, photographs and a precise description. Keep the reply with the batch file.

Who should do the inspection?

Someone trained in the receiving procedure who is not the only person to benefit from a quick release, so that the check is independent where possible.

Primary references

  1. FDA: Pharmaceutical Quality Control Laboratories Inspection Guide

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