What is Vesugen??
Vesugen (Lys-Glu-Asp, KED, molecular formula C15H26N4O8, MW 390.39 g/mol, PubChem CID 87571363) is a synthetic tripeptide bioregulator developed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Derived from vascular wall-associated proteins, Vesugen is investigated for its ability to interact with DNA minor grooves and promoter regions – modulating gene expression in endothelial cells and vascular smooth muscle. Key reported mechanisms include normalisation of endothelin-1 and connexin expression, restoration of eNOS gene activity, upregulation of SIRT1 (sirtuin-1), and reduction of Ki-67-driven senescent cell proliferation. It is classified as a Cytogen (synthetic short-peptide bioregulator) in the Khavinson bioregulator system.
Research Applications
Vascular Endothelial Gene Regulation
Endothelin-1 normalisation, connexin expression restoration, eNOS upregulation, ICAM-1/VCAM-1 adhesion molecule modulation
SIRT1 & Anti-Ageing Pathways
Sirtuin-1 upregulation, calorie-restriction-mimetic gene expression, SASP reduction in senescent endothelial cells
Atherosclerosis & Vascular Ageing
Endothelial dysfunction models, arterial stiffness, plaque formation studies – aged Wistar rat vascular experiments
Mesenchymal Stem Cell Research
MSC proliferation enhancement, senescence marker reduction, Ki-67 expression and cell differentiation control
Epigenetic & DNA Interaction
Peptide-DNA minor groove binding, histone complex interaction, promoter region modulation in vascular nuclei
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| Sequence | Lys-Glu-Asp (KED) |
| Molecular Formula | C15H26N4O8 |
| Molecular Weight | 390.39 g/mol |
| PubChem CID | 87571363 |
| Peptide Type | Synthetic tripeptide bioregulator / Khavinson Cytogen – vascular |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |