What is Tesofensine?
Tesofensine is a triple monoamine reuptake inhibitor — simultaneously blocking DAT, SERT, and NET. Originally developed for Parkinson’s and Alzheimer’s, it demonstrated exceptional appetite suppression and weight loss in Phase 2 obesity trials. Phase 2 (2008): 10.6% body weight reduction at 0.5mg/day over 24 weeks. CAS 195875-84-4.
Research Applications
Triple Reuptake Inhibition DAT/SERT/NET — hypothalamic appetite circuit modulation Obesity Pharmacology Phase 2: 10.6% weight reduction — comparison vs GLP-1R class Monoamine Neuroscience DA/5HT/NE selectivity and occupancy studies Energy Expenditure Sympathomimetic thermogenesis — BAT activation Addiction Research Dopamine reuptake inhibition — reward pathway pharmacology
Quick Specs
- Form
- Tablet — 500mcg per tablet, 100-tablet bottle
- CAS Number
- 195875-84-4
- Molecular Formula
- C₁₇H₂₃ClN₂O Molecular Weight 322.8 g/mol
- Compound Type
- Triple Monoamine Reuptake Inhibitor
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | cool, dry storage
- Shelf Life
- 24 months unopened
Certificate of Analysis (COA)
✓ Verify on Janoshik
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: USA 5–7 days International shipping: 7–14 days