What is Tesamorelin?
Tesamorelin is a stabilised full-length GHRH(1-44) analog — the only GHRH analog with FDA approval (Egrifta, 2010) for HIV-associated lipodystrophy. Full GHRH(1-44) sequence provides superior GHRHR binding vs sermorelin (1-29 fragment). Stimulates pulsatile GH release → IGF-1 → visceral fat reduction. Falutz 2010 (NEJM): 15.2% visceral fat reduction vs +5.0% placebo.
Research Applications
Visceral Fat Reduction
15.2% reduction — Falutz 2010 NEJM Phase 3 data
GHRH Analog Comparison
Full-length vs sermorelin (1-29) vs CJC-1295 GH pulse studies
NAFLD/Liver Fat
Stanley 2014: −37% liver fat by MRS — 6 months
IGF-1 Kinetics
Pulsatile GH → hepatic IGF-1 axis — vs direct rhGH
Body Composition
Lean mass preservation, visceral adiposity models
Quick Specs
| Form | Lyophilized powder — 5mg per vial, 10-vial kit |
| CAS Number | 218949-48-5 |
| Molecular Formula | C₂₂₁H₃₆₈N₇₂O₇₀S |
| Molecular Weight | 5135.9 g/mol |
| Compound Type | GHRH(1-44) Analog |
| Purity | ≥99% by HPLC — every batch |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU · UK · USA · Canada 5–7 days
International shipping: 7–14 days