What is TB-500?
TB-500 (Thymosin Beta-4 fragment (Ac-LKKTETQ)) is a 7-amino acid synthetic fragment. Sequesters G-actin to promote cell migration, activates an independent VEGF-mediated angiogenesis pathway, and modulates NF-κB to reduce inflammatory signalling. Non-overlapping with BPC-157 — complementary repair targets.
Research Applications
Cell Migration & Wound Repair
Actin sequestration enabling directed fibroblast/endothelial migration
Independent Angiogenesis
VEGF pathway activation distinct from BPC-157 NO/VEGF axis
Anti-Inflammatory
NF-κB modulation and inflammatory cytokine reduction
Cardiac Repair
Cardiomyocyte protection and cardiac tissue healing models
Muscle Repair
Skeletal muscle satellite cell activation and regeneration
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | Not officially assigned (synthetic peptide fragment) |
| Molecular Formula | C₂₁₂H₃₅₀N₅₆O₇₈S |
| Peptide Type | Synthetic Thymosin Beta-4 Fragment (Peptide) |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute TB-500?
Add 1–2mL bacteriostatic water to the lyophilized TB-500 vial. Swirl gently until dissolved — TB-500 (Thymosin Beta-4 fragment Ac-SDKP) dissolves readily to a clear solution. For large vials (10mg+), you may need to allow 5 minutes for full dissolution.
How should TB-500 be stored?
Store lyophilized at −20°C. Reconstituted TB-500 is stable at 2–8°C for up to 28 days. Keep away from direct light and avoid repeated freeze-thaw cycles of reconstituted solution.
What purity is Vesta TB-500 and how is it verified?
Vesta TB-500 is ≥99% pure by HPLC with MS-confirmed molecular identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU · UK · USA · AU · Canada 5–7 days
International shipping: 7–14 days