What is Tadalafil?
Tadalafil (Cialis — long-acting PDE5 inhibitor (~36hr half-life)) is a Small molecule C₂₂H₁₉N₃O₄, MW 389.4. Long-acting PDE5 inhibitor (half-life ~36hr vs 4–5hr sildenafil/vardenafil). Prevents cGMP degradation in smooth muscle, sustaining NO/cGMP-mediated vasodilation and relaxation. FDA approved for ED and pulmonary arterial hypertension (PAH).
High PDE5 selectivity over PDE1/3/4/6.
Research Applications
PDE5 Inhibition Biology cGMP phosphodiesterase inhibition, NO/cGMP pathway amplification Penile Smooth Muscle Research Corpus cavernosum relaxation, haemodynamic studies PAH Research FDA-approved PAH indication — pulmonary vascular resistance models Long-Acting PK 36hr half-life — sustained PDE5 inhibition pharmacokinetics vs Sildenafil/Vardenafil Duration, selectivity, and PDE isoform profile comparison
Quick Specs
- Form
- Oral tablets — pre-dosed
- Purity
- ≥99% by HPLC — every batch
- CAS Number
- 171596-29-5
- Molecular Formula
- C₂₂H₁₉N₃O₄, MW 389.4.
- Identity
- MS molecular weight confirmed — every batch
- Peptide Type
- Phosphodiesterase Type 5 (PDE5) Inhibitor
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house Fmoc SPPS — Qingdao, China
- Storage
- Room temperature (15–25°C), cool and dry
- Shelf Life
- As indicated by manufacturer
Certificate of Analysis (COA)
✓ Verify on Janoshik
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days