What is Tadalafil?
Tadalafil (Cialis) is a selective PDE5 inhibitor with the longest half-life in its class (~17.5hr, duration up to 36hr). Prevents cGMP degradation in smooth muscle, sustaining NO-mediated vasodilation. FDA-approved for erectile dysfunction, BPH, and pulmonary arterial hypertension (PAH/Adcirca). CAS 171596-29-5.
Research Applications
NO/cGMP Pathway PDE5 inhibition → sustained cGMP → smooth muscle relaxation Pulmonary Hypertension PAH vasodilation — Adcirca indication — pulmonary vascular resistance Long-Duration Protocol 17.5hr half-life — chronic dosing and sustained inhibition studies Cardiac Preload/Afterload Venodilation and arterial effects — cardiac function modelling vs PT-141 Pairing Peripheral PDE5 (tadalafil) + central MC4R (PT-141) — erectile physiology
Quick Specs
- Form
- Tablet — 20mg per tablet, 100-tablet bottle
- CAS Number
- 171596-29-5
- Molecular Formula
- C₂₂H₁₉N₃O₄ Molecular Weight 389.4 g/mol
- Compound Type
- PDE5 Inhibitor
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | cool, dry storage
- Shelf Life
- 24 months unopened
Certificate of Analysis (COA)
✓ Verify on Janoshik
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: USA 5–7 days International shipping: 7–14 days