What is SS-31?
SS-31 (Elamipretide — Bendavia — MTP-131 (cardiolipin-binding tetrapeptide)) is a 4-amino acid aromatic-cationic tetrapeptide. Aromatic-cationic tetrapeptide concentrating 1000× in the inner mitochondrial membrane by electrostatic and aromatic interactions with cardiolipin. Stabilises cristae architecture, preserves electron transport chain (ETC) complex I–IV organisation, reduces mitochondrial ROS production, and maintains ATP synthesis efficiency under ischemia and oxidative stress.
Research Applications
Cardiolipin Binding
Inner mitochondrial membrane cardiolipin interaction and cristae stabilisation
ETC Complex Preservation
Complex I–IV organisation under ischemia and oxidative stress
Mitochondrial ROS
Superoxide reduction at ETC, mitochondrial antioxidant research
Heart Failure Research
STELA, MEND-HF Phase 2 clinical reference compound
Neurodegeneration
Mitochondrial dysfunction in AD, PD, ALS models
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 736992-21-5 |
| Molecular Formula | C₃₂H₄₉N₉O₅ |
| Peptide Type | Mitochondria-Targeted Peptide |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
