What is Retatrutide?
Retatrutide (Triple GLP-1R/GIPR/GCGR agonist (LY3437943)) is a 39-amino acid triple-receptor peptide. Triple receptor co-agonist simultaneously activating GLP-1R, GIPR, and GCGR. GCGR activation adds thermogenesis, fatty acid oxidation, and hepatic glucose production modulation beyond dual GIP+GLP-1 agonism. Phase 2 (NEJM 2023): 24.2% mean weight reduction at 48 weeks (12mg dose).
Research Applications
Triple Receptor Pharmacology
GLP-1R + GIPR + GCGR co-agonism, additive receptor biology
GCGR Research
Isolated GCGR contribution vs tirzepatide (dual) in parallel arms
Obesity Models
Phase 2 NEJM 2023 reference — 24.2% weight reduction
Thermogenesis
GCGR-mediated fat oxidation and energy expenditure
NASH/Liver
Hepatic GCGR signalling and liver fat reduction
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | Not publicly standardized |
| Molecular Formula | Large synthetic peptide (sequence-specific; proprietary) |
| Peptide Type | Triple Receptor Agonist (GLP-1 / GIP / Glucagon Receptors) |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | As indicated by manufacturer |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute Retatrutide?
Add 1–2mL of bacteriostatic water slowly down the side of the vial. Do not shake — gently swirl until the lyophilized powder fully dissolves. The resulting solution should be clear and colourless. Use a 1mL insulin syringe for accurate sub-milligram dosing.
How should Retatrutide be stored?
Store lyophilized vials at −20°C (freezer). Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Keep away from light and repeated freeze-thaw cycles. Do not use if the solution is cloudy or contains visible particles.
What purity is Vesta Retatrutide and how is it verified?
Vesta Retatrutide is tested to ≥99% purity by analytical HPLC on every batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU · USA · AU 5–7 days
International shipping: 7–14 days