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Retatrutide 100mg | 20-Vial Kit | Triple GIP/GLP-1/Glucagon Agonist | Obesity & Metabolic Research
Anti-Aging & LongevityChinaPerformance & Hormone Optimization

Retatrutide 100mg | 20-Vial Kit | Triple GIP/GLP-1/Glucagon Agonist | Obesity & Metabolic Research

$1,350

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

0-Region Domestic Shipping Retatrutide (LY3437943 / triple incretin agonist, CAS 2381932-72-3) 100mg — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. International shipping: 7–14 days

SKU
VES-RT100-RETATRUTIDE-100MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
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What is Retatrutide??

Retatrutide (LY3437943, CAS 2381932-72-3) is a 39-amino acid triple-receptor agonist simultaneously activating the GIP receptor (GIPR), GLP-1 receptor (GLP-1R), and glucagon receptor (GCGR) — the first clinically investigated triagonist incretin peptide. Developed by Eli Lilly, it incorporates a C18 fatty diacid moiety for albumin binding, yielding a half-life of approximately 6 days. Phase 2 data demonstrated up to ~24% body weight reduction — exceeding tirzepatide (dual GIP/GLP-1) — primarily attributed to the additive glucagon receptor arm driving hepatic fat oxidation, thermogenesis, and appetite suppression independent of insulin secretion. Retatrutide is the leading research tool for dissecting the individual and combined contributions of all three incretin-related receptor axes.

Research Applications

Triple Receptor Dissection

GIPR vs. GLP-1R vs. GCGR individual arm contributions — selective antagonist co-treatment designs

Obesity & Thermogenesis

GCGR-mediated energy expenditure, brown adipose UCP1, hepatic fat oxidation — beyond dual incretin

Glucose Homeostasis

Triple incretin insulin secretion, glucagon regulation balance, hepatic glucose output at GCGR

NAFLD/NASH Research

Hepatic steatosis, liver fat quantification, fibrosis biomarkers under triple agonism

vs Tirzepatide Comparison

Dual (tirzepatide) vs. triple (retatrutide) incretin: weight loss depth, metabolic breadth, receptor kinetics

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number 2381932-72-3
Also Known As LY3437943, triple incretin agonist
Molecular Weight ~4681 Da
Half-Life ~6 days (C18 fatty diacid albumin binding)
Receptors GIPR + GLP-1R + GCGR (triple agonist)
Peptide Type Synthetic triple incretin receptor agonist — triagonist
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute Retatrutide?
Add 1–2mL of bacteriostatic water slowly down the side of the vial. Do not shake — gently swirl until the lyophilized powder fully dissolves. The resulting solution should be clear and colourless. Use a 1mL insulin syringe for accurate sub-milligram dosing.
How should Retatrutide be stored?
Store lyophilized vials at −20°C (freezer). Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Keep away from light and repeated freeze-thaw cycles. Do not use if the solution is cloudy or contains visible particles.
What purity is Vesta Retatrutide and how is it verified?
Vesta Retatrutide is tested to ≥99% purity by analytical HPLC on every batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.