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PNC-27 5mg | 20-Vial Kit | Anticancer Peptide Kit
Anti-Aging & LongevityAustraliaCanadaChinaUnited States

PNC-27 5mg | 20-Vial Kit | Anticancer Peptide Kit

$430

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

3-Region Domestic Shipping PNC-27 5mg | 20-Vial Kit — p53-derived proapoptotic peptide — penetrates HDM-2-overexpressing cancer cell membranes to trigger membranolytic apoptosis selectively in tumour cells that overexpress HDM-2. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. Domestic shipping: USA · AU · Canada 5–7 days International shipping: 7–14 days

SKU
VES-PN5-PNC27-5MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
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What is PNC-27?

PNC-27 (HDM2-targeting chimeric anticancer peptide) is a 32-amino acid chimeric peptide (HDM2-binding + penetratin). Chimeric peptide combining an HDM2 (human double minute 2)-binding domain with a penetratin cell-penetrating sequence. Proposed mechanism: binds membrane-associated HDM2 overexpressed on cancer cell surfaces, disrupting p53-HDM2 interaction and inducing selective cancer cell membranolysis while sparing normal cells.

Research Applications

HDM2-p53 Disruption

Protein interaction inhibition at MDM2/HDM2-p53 interface

Cancer-Selective Lysis

Membrane-targeted anticancer peptide mechanism research

Cell Penetrating Delivery

Penetratin-mediated intracellular delivery system biology

Cancer vs Normal Cells

Selectivity mechanism — HDM2 overexpression in cancer

vs Small Molecule MDM2i

Comparison with nutlin-3, AMG-232 mechanism and selectivity

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number Not publicly standardized
Molecular Formula Sequence-dependent (33-amino-acid peptide)
Peptide Type Synthetic Peptide / p53-MDM2 Interaction Inhibitor
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Vesta COA Report

✓ Verify on Janoshik

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: USA  ·  AU  ·  Canada 5–7 days
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.