Research use only · Multi-region fulfillment · Support-assisted ordering
VestaResearch Supply
PE-22-28 10mg | 20-Vial Kit | Progerin-Targeting
AsiaAustraliaChinaEuropean UnionRecovery & HealingUnited States

PE-22-28 10mg | 20-Vial Kit | Progerin-Targeting

$370

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

3-Region Domestic Shipping Vesta PE-22-28 (Spadin analog, TREK-1 blocker) — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. Domestic shipping: EU · USA · AU 5–7 days International shipping: 7–14 days

SKU
VES-PE10-PE2228-10MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
Ask on Telegram

What is PE-22-28?

PE-22-28 (Spadin analog — TREK-1 potassium channel blocker) is a 7-amino acid synthetic spadin-derived peptide. Synthetic spadin-derived peptide blocking the TREK-1 (TRAAK-related potassium channel-1) two-pore-domain K⁺ channel, which is overexpressed in depression models and reduces neuronal excitability. TREK-1 blockade increases firing rate and serotonin release — antidepressant mechanism without SSRI profile or sedation.

Research Applications

TREK-1 Channel Pharmacology

Two-pore-domain K⁺ channel block — neuronal excitability increase

Antidepressant Biology

Depression model research without SSRI target or sedation

Sortilin/Spadin Axis

Sortilin propeptide biology, TREK-1 regulation mechanism

Serotonin Release

5-HT release augmentation via neuronal depolarisation

Ion Channel Research

K⁺ channel pharmacology, membrane potential, firing rate studies

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number Not publicly standardized
Molecular Formula Sequence-dependent (7-amino-acid peptide)
Peptide Type Synthetic Peptide / Progerin-Targeting Fragment
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Vesta COA Report

✓ Verify on Janoshik

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU  ·  USA  ·  AU 5–7 days
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.