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P21-adamantane 10mg | 10-Vial Kit | CNTF Nootropic Peptide
ChinaCognitive & Nootropic

P21-adamantane 10mg | 10-Vial Kit | CNTF Nootropic Peptide

$420

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

China Warehouse P21-adamantane 10mg | 10-Vial Kit | Adamantane-modified CNTF-derived peptide — hippocampal neurogenesis, BDNF upregulation, and cognitive research. ≥99% HPLC purity, Janoshik COA. Research use only. International shipping: 7–14 days

SKU
VES-PP10-P21ADAMANTANE-10MG-10VIAL
Format
0.22 lbs
Use
Laboratory research only
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What is P21-adamantane?

P21-adamantane is a modified neurotrophin-mimetic peptide derived from the CNTF (ciliary neurotrophic factor) sequence, with an adamantane moiety attached to enhance blood-brain barrier penetration and receptor engagement. Activates STAT3/JAK signalling and BDNF expression. Studied for hippocampal neurogenesis, cognitive enhancement, and neuroprotection models, with the adamantane modification providing superior CNS bioavailability compared to unmodified P21. Research use only.

Research Applications

Hippocampal Neurogenesis

Dentate gyrus progenitor cell proliferation, BrdU/EdU incorporation, DCX expression

BDNF Upregulation

BDNF mRNA and protein expression, TrkB signalling, CREB phosphorylation

STAT3/JAK Pathway Research

CNTF receptor complex activation, STAT3 nuclear translocation, target gene profiles

Blood-Brain Barrier Penetration

Adamantane moiety CNS uptake vs unmodified peptide — pharmacokinetic comparison

Cognitive & Memory Research

Morris water maze, novel object recognition, LTP modulation in rodent models

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number 2411025-13-3
Molecular Formula Adamantane-AEAEAAAKEAAAKAAE (modified CNTF loop), MW ~2,200 Da
Identity MS molecular weight confirmed — every batch
Peptide Type CNTF-Derived Nootropic / Neurogenic Peptide
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (3 weeks)
Shelf Life 24 months (unopened)

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute P21-adamantane?
Add 1 mL bacteriostatic water to the lyophilized vial, directing liquid down the inner wall. Swirl gently until clear — takes 2–3 minutes due to the hydrophobic adamantane modification. Slight warming to 37°C can aid dissolution if needed.
How should P21-adamantane be stored?
Store lyophilized vials at −20°C. Reconstituted solution is stable at 2–8°C for up to 3 weeks. The adamantane moiety is susceptible to aggregation at high concentrations — avoid freeze-thaw cycling.
What is the significance of the adamantane modification in P21?
Adamantane is a lipophilic cage molecule that dramatically improves CNS penetration by facilitating passage through the blood-brain barrier. P21-adamantane shows superior hippocampal BDNF upregulation and neurogenesis compared to the unmodified P21 peptide in published research models.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.