What is Orforglipron?
Orforglipron (Oral non-peptide allosteric GLP-1R agonist) is a Small molecule (MW ~450, non-peptide). First non-peptide GLP-1R agonist approved (2025). Activates GLP-1R via allosteric (not orthosteric) binding — enabling oral bioavailability without peptide backbone. Biased agonism profile differs from peptide GLP-1R agonists.
ATTAIN Phase 3: ~14.7% weight reduction at 36 weeks.
Research Applications
Allosteric GLP-1R Agonism Allosteric vs orthosteric receptor binding comparison research Oral Bioavailability No injection stress confound — oral GLP-1R biology in rodent models Biased Signalling Small molecule vs peptide GLP-1R agonist downstream bias Obesity Research ATTAIN Phase 3 reference — 14.7% weight reduction at 36 weeks vs Injectable GLP-1R Mechanism and downstream signalling comparison
Quick Specs
- Form
- Oral tablets — pre-dosed
- Purity
- ≥99% by HPLC — every batch
- CAS Number
- 2211316-73-5
- Identity
- MS molecular weight confirmed — every batch
- Peptide Type
- Small Molecule GLP-1 Receptor Agonist
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house Fmoc SPPS — Qingdao, China
- Storage
- Room temperature (15–25°C), cool and dry
- Shelf Life
- 24 months sealed
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: USA 5–7 days International shipping: 7–14 days