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Orexin B 10mg | 10-Vial Kit | Hypocretin-2 High-Dose | OX2R Research
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Orexin B 10mg | 10-Vial Kit | Hypocretin-2 High-Dose | OX2R Research

$350

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

0-Region Domestic Shipping Orexin B 10mg | 10-Vial Kit — Orexin-B (Hypocretin-2) — 28aa linear neuropeptide preferentially activating OX2R over OX1R to regulate sleep-wake transitions and energy homeostasis; studied in arousal and metabolic research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. International shipping: 7–14 days

SKU
VES-OREB10-OREXINB-10MG-10VIAL
Format
0.22 lbs
Use
Laboratory research only
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What is Orexin B (High-Dose)??

Orexin B (Hypocretin-2, CAS 205640-91-1) is a 28-amino acid OX2R-selective hypothalamic neuropeptide. This 10mg/vial high-dose format supports research protocols requiring larger quantities – dose-escalation OX2R receptor occupancy studies, multi-cohort sleep paradigms, high-throughput competitive binding assays, or extended in vivo infusion experiments investigating OX2R-mediated histaminergic arousal, sleep-wake architecture, or suvorexant mechanism-of-action comparisons. The 10mg format also enables combination assays comparing Orexin B (OX2R-selective) vs. Orexin A (OX1R/OX2R dual) biology side-by-side with adequate quantities for both arms.

Research Applications

High-Dose OX2R Occupancy

Dose-escalation receptor saturation kinetics, Bmax/Kd determination in hypothalamic membrane preparations

Multi-Cohort Sleep Studies

Sufficient for large-animal or multi-arm sleep EEG studies requiring repeated orexin B administration

High-Throughput Receptor Screening

Competitive binding assays – Orexin B as OX2R radioligand competitor against novel antagonist libraries

Suvorexant Mechanism Studies

OX2R occupancy correlation with sleep onset/maintenance – comparison with dual OX1R/OX2R blockade

Comparative Orexin Biology

Orexin A vs. B functional comparison assay – OX1R-specific phenotypes vs. OX2R-specific phenotypes with 10mg of each

Quick Specs

Form Lyophilized powder
Purity >=99% by HPLC – every batch
CAS Number 205640-91-1
Also Known As Hypocretin-2, HCRT2
Sequence Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
Receptor Selectivity OX2R-preferring (~5-100x vs. OX1R) – 10mg/vial high-dose
Peptide Type Endogenous 28-aa hypothalamic neuropeptide / OX2R-selective agonist – high dose
Identity MS molecular weight confirmed – every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS – Qingdao, China
Storage -20C sealed | 2-8C reconstituted (2-4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators – reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.