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Orexin A 10mg | 20-Vial Kit | Hypocretin-1 | Wakefulness & Narcolepsy Research
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Orexin A 10mg | 20-Vial Kit | Hypocretin-1 | Wakefulness & Narcolepsy Research

$1,150

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

0-Region Domestic Shipping Orexin A 10mg | 20-Vial Kit — Orexin-A (Hypocretin-1) — 33aa neuropeptide with two disulfide bridges activating OX1R/OX2R to regulate wakefulness, arousal, and appetite; studied in narcolepsy and metabolic models. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. International shipping: 7–14 days

SKU
VES-OREA10-OREXINA-10MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
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What is Orexin A??

Orexin A (Hypocretin-1, CAS 205599-75-3) is a 33-amino acid hypothalamic neuropeptide produced from prepro-orexin by enzymatic cleavage. It has an N-terminal pyroglutamyl residue, two intramolecular disulfide bridges (Cys6-Cys12, Cys7-Cys14), and C-terminal amidation. MW 3562.14 g/mol. Orexin A is produced exclusively in a small population (~50,000-80,000) of lateral hypothalamic neurons and projects widely through the CNS. It binds both OX1R and OX2R receptors (Gq-coupled) with approximately equal high affinity – activating arousal circuits involving norepinephrine (locus coeruleus), dopamine, histamine, and acetylcholine systems. Loss of orexin-producing neurons causes narcolepsy type 1 – the definitive disease model for the orexin system. Orexin A also modulates feeding behaviour, reward/motivation, stress responses, and energy homeostasis.

Research Applications

Sleep/Wake & Arousal Research

OX1R/OX2R-mediated wakefulness stabilisation, narcolepsy/cataplexy models, hypocretin neuron ablation studies

Narcolepsy Models

Orexin deficiency rescue in orexin knockout mice, ICV administration cognitive restoration in sleep-deprived primates

Appetite & Feeding Behaviour

Orexigenic signalling, lateral hypothalamic feeding circuits, NPY/orexin interaction, fasting-induced prepro-orexin upregulation

Reward & Addiction

OX1R role in drug-seeking, reward salience, cocaine/opioid cue-induced reinstatement models

Energy Homeostasis

Glucose-sensing orexin neurons, tandem pore K+ channel glucose inhibition, OX2R feeding and adiposity regulation

Quick Specs

Form Lyophilized powder
Purity >=99% by HPLC – every batch
CAS Number 205599-75-3
Also Known As Hypocretin-1, HCRT1
Sequence pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 [Cys6-Cys12, Cys7-Cys14]
Molecular Weight 3562.14 g/mol
Receptors OX1R + OX2R – equal high affinity (vs. Orexin B selective OX2R)
Peptide Type Endogenous 33-aa hypothalamic neuropeptide / dual OX1R/OX2R agonist
Identity MS molecular weight confirmed – every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS – Qingdao, China
Storage -20C sealed | 2-8C reconstituted (2-4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators – reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.