What is KPV?
KPV (Lys-Pro-Val) is the biologically active C-terminal tripeptide of α-melanocyte-stimulating hormone (α-MSH).
Despite lacking the melanotropic N-terminal region of α-MSH, KPV retains potent anti-inflammatory activity — acting via MC1R and intracellular mechanisms to suppress NF-κB activation, reduce pro-inflammatory cytokine production, and protect intestinal epithelial barrier integrity. Research use only.
Research Applications
MC1R Anti-Inflammatory Signalling Receptor-mediated cAMP elevation, NF-κB suppression, cytokine modulation Intestinal Inflammation Research Gut epithelial barrier protection, IBD models, tight junction preservation Intracellular Anti-Inflammatory Direct nuclear NF-κB inhibition independent of surface receptor — dual mechanism Skin & Wound Inflammation Dermal
anti-inflammatory activity, keratinocyte cytokine suppression, wound healing Comparative α-MSH Research KPV tripeptide vs full-length α-MSH and Melanotan II — receptor selectivity
Quick Specs
- Form
- Tablet — 500mcg per tablet, 100-tablet bottle
- CAS Number
- 69661-79-6
- Molecular Formula
- C₁₅H₂₈N₄O₅ Molecular Weight 344.4 g/mol
- Compound Type
- α-MSH C-Terminal Tripeptide / MC1R Anti-Inflammatory
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | cool, dry storage
- Shelf Life
- 24 months unopened
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days