What is Isotretinoin?
Isotretinoin (13-cis-retinoic acid) is a synthetic retinoid — the most potent oral sebosuppressive agent known. Binds RARα/β/γ and RXR nuclear receptors, reducing sebaceous gland size and activity, inducing apoptosis in sebocytes, and normalising keratinocyte differentiation.
Additionally studied for anti-inflammatory, anti-proliferative (neuroblastoma), and differentiating effects. Research use only.
Research Applications
Sebaceous Gland Biology Sebocyte apoptosis, sebum production suppression, SCD1/FASN pathway RAR/RXR Receptor Pharmacology Retinoid receptor binding, retinoic acid response element (RARE) activation Keratinocyte Differentiation Follicular hyperkeratinisation inhibition, comedogenesis models, skin barrier Neuroblastoma Differentiation Neural crest cell differentiation, MYCN suppression, neurite outgrowth Anti-Inflammatory Skin Research Innate immune pathway modulation in sebaceous gland inflammation, TLR2 signalling
Quick Specs
- Form
- Tablet — 10mg per tablet, 100-tablet bottle
- CAS Number
- 4759-48-2
- Molecular Formula
- C₂₀H₂₈O₂ Molecular Weight 300.4 g/mol
- Compound Type
- Retinoid / Retinoic Acid Isomer
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | protect from light | cool, dry storage
- Shelf Life
- 24 months unopened
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days