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FOXO4-DRI 5mg | 20-Vial Kit | Anti-Aging
Anti-Aging & LongevityAsiaChinaUnited States

FOXO4-DRI 5mg | 20-Vial Kit | Anti-Aging

$650

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

1-Region Domestic Shipping Vesta FOXO4-DRI (FOXO4-p53 interaction inhibitor) — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. Domestic shipping: · International shipping: 7–14 days

SKU
VES-F405-FOXO4DRI-5MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
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What is FOXO4-DRI?

FOXO4-DRI (FOXO4-p53 interaction inhibitor — senolytic D-peptide) is a 18-amino acid retro-inverso D-amino acid peptide. Retro-inverso D-peptide disrupting the FOXO4-p53 protein-protein interaction in senescent cells, enabling p53 nuclear export and intrinsic apoptosis specifically in p21-high senescent cells. Spares normal proliferating and quiescent cells — selective senolytic without systemic toxicity in mouse models.

Research Applications

Senolytic Research

Selective senescent cell clearance — p21-high cell apoptosis

FOXO4-p53 Biology

Protein-protein interaction disruption, p53 nuclear localisation

Cellular Senescence

p21/p16 pathway, SA-β-gal markers, SASP reduction models

Healthspan Extension

Aged and fast-ageing mouse model healthspan and tissue function

vs Other Senolytics

Comparison with navitoclax, dasatinib+quercetin mechanism

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number Not publicly standardized
Molecular Formula Sequence-specific peptide (FOXO4-derived D-retro-inverso analog)
Peptide Type Senolytic Peptide / FOXO4-p53 Interaction Inhibitor
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Vesta COA Report

✓ Verify on Janoshik

Frequently Asked Questions

How do I reconstitute FOXO4-DRI?
Add 1–2mL bacteriostatic water to the lyophilized FOXO4-DRI vial. FOXO4-DRI is a D-retro-inverso peptide and dissolves readily. Swirl gently until the solution is clear and colourless.
How should FOXO4-DRI be stored?
Store lyophilized at −20°C. Reconstituted: 2–8°C for up to 28 days. D-retro-inverso peptides are highly resistant to proteolytic degradation due to their mirror-image backbone — FOXO4-DRI is more stable than equivalent L-amino acid peptides.
What purity is Vesta FOXO4-DRI and how is it verified?
Vesta FOXO4-DRI is ≥99% pure by HPLC with MS-confirmed molecular weight on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.