What is FOXO4-DRI??
FOXO4-DRI (also called FOXO4-D-Retro-Inverso or FOXO4 p53-Interaction Domain Peptide) is a D-retro-inverso stapled peptide designed to antagonise the interaction between FOXO4 and p53 in senescent cells. In non-senescent cells, p53 localises to mitochondria to trigger apoptosis when activated. In senescent cells, FOXO4 sequesters p53 in the nucleus, suppressing this apoptotic programme and enabling senescent cell survival (SASP). FOXO4-DRI disrupts this FOXO4–p53 interaction, restoring nuclear p53 export → mitochondrial translocation → apoptosis selectively in senescent cells — without affecting normal proliferating cells.
Research Applications
Senescent Cell Clearance
FOXO4–p53 interaction disruption, selective senolysis without toxicity to normal cells
p53 Pathway Biology
Nuclear p53 localisation vs. mitochondrial apoptosis, p53-Puma-Bcl-w-interaction profiling
SASP Modulation
Senescence-associated secretory phenotype cytokine reduction after senolytic clearance
Ageing & Tissue Restoration
Liver, kidney, and intestinal tissue rejuvenation models; hair follicle restoration
Senolytic vs. Senostatic Comparison
FOXO4-DRI vs. dasatinib/quercetin: mechanism, selectivity, and tissue distribution
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| Peptide Type | D-retro-inverso stapled peptide / senolytic |
| Target | FOXO4–p53 protein–protein interaction |
| Selectivity | Senescent cells — spares normal proliferating cells |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
