What is DNP (2,4-Dinitrophenol)?
2,4-Dinitrophenol (DNP) is a protonophore and mitochondrial uncoupler — dissipates the proton gradient across the inner mitochondrial membrane, uncoupling electron transport chain activity from ATP synthesis. This forces increased substrate oxidation and dramatically raises metabolic rate and thermogenesis.
DNP is the canonical research tool for mitochondrial uncoupling, bioenergetics, and proton leak studies. Research use only. Note: DNP has an extremely narrow therapeutic index and is highly toxic at doses only modestly above research concentrations — handle with appropriate laboratory precautions.
Research Applications
Mitochondrial Uncoupling Proton leak quantification, respiratory control ratio, membrane potential dissipation Thermogenesis Research Heat production from uncoupled respiration, body temperature models, metabolic rate Bioenergetics Studies ATP synthesis inhibition, substrate oxidation flux, oxygen consumption rate (OCR) Brown Adipose Tissue Research UCP1 vs
chemical uncoupling comparison, thermogenic capacity studies Metabolic Rate & Fat Oxidation Accelerated substrate use, fat oxidation kinetics, energy balance studies
Quick Specs
- Form
- Tablet — 200mg per tablet, 50-tablet bottle
- CAS Number
- 51-28-5
- Molecular Formula
- C₆H₄N₂O₅ Molecular Weight 184.1 g/mol
- Compound Type
- Mitochondrial Uncoupler / Protonophore
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Cool, dry storage | away from heat sources | handle with care
- Shelf Life
- 24 months unopened
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days