What is Dihexa?
Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is an angiotensin IV analogue that potently activates the HGF/c-Met receptor signalling pathway — reported to be ~10⁷× more potent than BDNF in synaptogenesis assays. HGF/c-Met activation promotes dendritic spine formation, hippocampal synaptic density, and neuronal repair.
Studied as a cognitive enhancer, synaptogenic agent, and neurodegeneration research tool. Research use only.
Research Applications
HGF/c-Met Receptor Signalling c-Met activation, downstream ERK/PI3K/Akt cascades, receptor specificity Synaptogenesis Research Dendritic spine density, synapse formation, pre/postsynaptic marker expression Cognitive Enhancement Models Morris water maze, novel object recognition, Barnes maze — hippocampal-dependent learning Neurodegeneration Research Alzheimer’s, Parkinson’s, TBI models — synaptic density preservation BDNF Pathway Comparison Dihexa vs BDNF, NGF — synaptogenesis potency, receptor pathway overlap
Quick Specs
- Form
- Tablet — 20mg per tablet, 25-tablet bottle
- CAS Number
- 1172133-28-6
- Molecular Formula
- C₁₅H₂₃N₃O₄ (angiotensin IV analogue) Molecular Weight 309.4 g/mol
- Compound Type
- HGF/c-Met Agonist / Cognitive Enhancement Peptide
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | cool, dry storage | protect from light
- Shelf Life
- 24 months unopened
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days