What is CJC-1295 (With DAC)??
CJC-1295 With DAC (Drug Affinity Complex) is a long-acting GHRH analog that chemically conjugates to plasma albumin via a maleimido-propionamide linker, extending its half-life from ~30 minutes (No DAC) to approximately 6–8 days. This results in sustained, non-pulsatile elevation of circulating GH and IGF-1 — making it a distinct experimental tool for studying continuous vs. pulsatile GH release and downstream metabolic consequences. Molecular formula C₁₆₅H₂₇₁N₄₃O₄₆S, MW ~3648 g/mol.
Research Applications
Albumin-Binding Pharmacokinetics
DAC-albumin conjugation half-life studies, sustained plasma exposure profiling
Non-Pulsatile GH Release
Tonic vs. pulsatile GH secretion, GHRH receptor occupancy, receptor downregulation
IGF-1 Axis
Sustained hepatic IGF-1 induction, GH:IGF-1 ratio studies over multi-day windows
Body Composition
Lean mass, lipolysis, and nitrogen balance in continuous GH elevation models
Comparison Studies
CJC-1295 DAC vs. No DAC: T½, GH pulse profile, receptor desensitisation differences
Quick Specs
| Form | Lyophilized powder |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 863288-34-0 (DAC variant) |
| Half-Life | ~6–8 days (albumin-bound) |
| Molecular Weight | ~3648 g/mol |
| Peptide Type | Synthetic long-acting GHRH analog — albumin-binding DAC linker |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
