What is Cardiogen??
Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide bioregulator developed by Prof. Vladimir Khavinson’s team at the St. Petersburg Institute of Bioregulation and Gerontology. It belongs to the Cytogen family of synthetic Khavinson peptides – precise copies of the active site sequences found in cardiac tissue extracts. Cardiogen is investigated for its tissue-specific ability to penetrate to the cell nucleus and interact with DNA promoter regions in cardiomyocytes and cardiac fibroblasts – modulating gene expression programs linked to myocardial repair, protein synthesis restoration, fibrosis-associated ECM remodelling, and apoptosis regulation. Research applications span post-infarction remodelling, hypertension-induced cardiac hypertrophy, and fibroblast signalling relevant to both cardiac and prostate tissue microenvironments.
Research Applications
Cardiomyocyte Gene Regulation
DNA promoter interaction in cardiac tissue, protein synthesis restoration, myocardial metabolic gene expression profiling
Post-Infarction Remodelling
Myocardial tissue culture recovery, infarct model fibrosis reduction, cardiomyocyte survival and contractile protein expression
Cardiac Fibroblast Biology
Fibroblast ECM remodelling, TGF-beta/collagen signalling, fibrosis-associated microenvironment studies
Neuroprotective & CNS Gene Expression
Brain cortex gene expression profiling (microarray), neuronoprotective membrane potential effects – heart/brain dual target
Anti-Ageing & Geroprotection
Age-related cardiac decline reversal, myocardial tissue culture from young vs. aged rats, protein synthesis comparison
Quick Specs
| Form | Lyophilized powder |
| Purity | >=99% by HPLC – every batch |
| Sequence | Ala-Glu-Asp-Arg (AEDR) |
| Peptide Type | Synthetic tetrapeptide bioregulator / Khavinson Cytogen – cardiac |
| Target Tissue | Cardiomyocytes, cardiac fibroblasts – tissue-specific nuclear DNA interaction |
| Identity | MS molecular weight confirmed – every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS – Qingdao, China |
| Storage | -20C sealed | 2-8C reconstituted (2-4 weeks) |
| Shelf Life | 24 months unopened |