What is AICAR?
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an AMP mimetic that activates AMP-activated protein kinase (AMPK) — the master cellular energy sensor. AICAR enters cells and is phosphorylated to ZMP, which mimics the effect of elevated AMP:ATP ratio.
Activates AMPK downstream pathways: fatty acid oxidation, glucose uptake, mitochondrial biogenesis, autophagy, and inhibition of mTORC1. Classic research tool for energy sensing biology. Research use only.
Research Applications
AMPK Activation Classic AMPK activator — phospho-AMPK, downstream ACC/HMGCR/TSC2 phosphorylation Exercise Mimetic Research AICAR-activated endurance gene programs — running capacity, fibre type shift models Glucose Metabolism GLUT4 translocation, glucose uptake, insulin-independent pathway research Fatty Acid Oxidation CPT1 derepression, mitochondrial β-oxidation flux, ketogenesis Autophagy & mTOR Inhibition mTORC1 suppression via AMPK-TSC2 axis, ULK1 activation, autophagy flux
Quick Specs
- Form
- Tablet — 10mg per tablet, 100-tablet bottle
- CAS Number
- 2627-69-2
- Molecular Formula
- C₉H₁₄N₄O₈P Molecular Weight 338.2 g/mol
- Compound Type
- AMPK Activator / AMP Mimetic
- Purity
- ≥99% by HPLC — every batch
- Identity
- MS molecular weight confirmed — every batch
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house synthesis — Qingdao, China
- Storage
- Room temperature sealed | cool, dry storage
- Shelf Life
- 24 months unopened
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days