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ACE-031 1mg | 20-Vial Kit | Myostatin Inhibitor | ActRIIB-Fc Fusion Protein Research
AsiaChinaPerformance & Hormone Optimization

ACE-031 1mg | 20-Vial Kit | Myostatin Inhibitor | ActRIIB-Fc Fusion Protein Research

$410

In stock

For in vitro laboratory research only. Not for human or veterinary consumption.

0-Region Domestic Shipping ACE-031 1mg | 20-Vial Kit — Soluble ActRIIB-Fc fusion (Ramatercept) — sequesters myostatin, activin A, and BMP ligands by acting as decoy receptor, studied for muscle wasting and bone density research. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. International shipping: 7–14 days

SKU
VES-AE1-ACE031-1MG-20VIAL
Format
0.42 lbs
Use
Laboratory research only
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What is ACE-031??

ACE-031 (also known as Ramatercept, CAS 1621169-52-5) is a recombinant fusion protein composed of the extracellular ligand-binding domain of activin receptor type IIB (ACVR2B) linked to the Fc region of human IgG1. It functions as a soluble decoy receptor, sequestering myostatin (GDF-8), activin A, activin B, GDF-11, and BMP-9 in circulation — preventing these negative regulators from binding membrane-bound ACVR2B on muscle and bone cells. Developed by Acceleron Pharma, ACE-031 has a half-life of approximately 10–15 days in human pharmacokinetic studies.

Research Applications

Myostatin / ACVR2B Signalling

Myostatin-SMAD2/3 pathway suppression, receptor downregulation, ligand-trap kinetics

Skeletal Muscle Biology

Fiber cross-sectional area hypertrophy, anabolic protein synthesis, DMD & ALS wasting models

Bone Metabolism

Biomarker shifts in bone formation vs. resorption, lumbar spine mineral density studies

Fat Metabolism

Adipose lipolysis changes associated with ActRIIB ligand inhibition

Pharmacokinetics

AUC(0-∞), Cmax linear dose-response, T½ 10–15 day profiling

Quick Specs

Form Lyophilized powder
Purity ≥99% by HPLC — every batch
CAS Number 1621169-52-5
Molecular Formula C₃₄₁₈H₅₁₈₈N₉₂₈O₁₀₆₂S₃₈
Molecular Weight ~57.3 kDa
Peptide Type Recombinant Fusion Protein (ActRIIB-IgG1-Fc)
Identity MS molecular weight confirmed — every batch
COA Janoshik-independent, publicly verifiable
Manufacture In-house Fmoc SPPS — Qingdao, China
Storage -20°C sealed | 2–8°C reconstituted (2–4 weeks)
Shelf Life 24 months unopened

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days
Research use only

This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.