What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium — NNMT inhibitor) is a Small molecule (C₁₀H₁₀N₂, MW 174.2). Competitive NNMT (nicotinamide N-methyltransferase) inhibitor preventing nicotinamide from being diverted away from the NAD+ salvage pathway. Preserves SAM methyl donor pool and improves SAM/SAH ratio for epigenetic methylation.
Indirect NAD+ increase → SIRT1 activation → PGC-1α → mitochondrial biogenesis.
Research Applications
NNMT Inhibition Competitive enzyme inhibition — NAD+ precursor preservation Indirect NAD+ Upregulation Salvage pathway restoration vs direct NR/NMN supplementation Adipogenesis Suppression PRDM16 methylation preservation → white vs brown adipocyte fate SIRT1/PGC-1α Axis NAD+-dependent sirtuin activation and mitochondrial biogenesis SAM/SAH Methylation Epigenetic methylation biology and methyl donor pool research
Quick Specs
- Form
- Oral tablets — pre-dosed
- Purity
- ≥99% by HPLC — every batch
- CAS Number
- Not officially assigned
- Molecular Formula
- C₁₀H₁₀N₂, MW 174.2
- Identity
- MS molecular weight confirmed — every batch
- Peptide Type
- Small Molecule NNMT Inhibitor
- COA
- Janoshik-independent, publicly verifiable
- Manufacture
- In-house Fmoc SPPS — Qingdao, China
- Storage
- Room temperature (15–25°C), cool and dry
- Shelf Life
- 24 months sealed
Certificate of Analysis (COA)
✓ Verify on Janoshik
Frequently Asked Questions
How are Vesta research tablets supplied?
Vesta research tablets are supplied as pre-dosed oral tablets at the stated concentration.
No reconstitution is required. Each tablet is compressed at uniform dose for consistent dosing in research applications. How should research tablets be stored?
Store at room temperature (15–25°C) in a cool, dry place away from moisture, heat, and direct sunlight.
Keep in the original container. Properly stored tablets remain stable for 2–3 years. What purity are Vesta research tablets and how is it verified?
Vesta research tablets contain active ingredient at ≥99% HPLC purity before tableting, with MS-confirmed identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com. Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
International shipping: 7–14 days