What is Lefra 20mg (LEFLUNOMIDE)?
DMARD for rheumatoid arthritis and psoriatic arthritis. Second-line after methotrexate failure or intolerance. Once-daily dosing due to long half-life of active metabolite.
How it Works
Prodrug converted to teriflunomide — inhibits DHODH, blocking de novo pyrimidine synthesis in proliferating T and B cells — reduces immune-mediated joint inflammation.
Quick Specs
- Form
- Oral tablets — pre-dosed
- Active Ingredient
- LEFLUNOMIDE
- Dose per Tablet
- 20MG
- Pack Size
- 10×10 (100 tablets)
- Storage
- Room temperature (15–25°C), cool dry place
- Shelf Life
- 2–3 years (properly stored)
Common Side Effects
Diarrhea (most common), nausea, hair loss (usually mild), rash, elevated liver enzymes, hypertension, peripheral neuropathy (rare).
Safety Warnings
TERATOGENIC — pregnancy absolutely contraindicated. Accelerated elimination procedure (cholestyramine) required before pregnancy. Hepatotoxicity monitoring — especially combined with methotrexate. International shipping: 7–14 days