What is Hexarelin?
Hexarelin (His-DTrp-Ala-Trp-DPhe-Lys-NH₂) is a synthetic hexapeptide GHSR-1a agonist producing the highest GH pulse amplitude of any synthetic GHRP. Uniquely, hexarelin also binds the CD36 scavenger receptor in cardiac tissue — providing GH-independent cardioprotection via PI3K/Akt signalling. CAS 140703-51-1.
Research Applications
Maximum GH Pulse
Highest intrinsic GHSR-1a efficacy — strongest GH release of all GHRPs
CD36 Cardiac Research
GH-independent cardioprotection — PI3K/Akt — unique among synthetic GHRPs
Cardiac IR Protection
LAD ligation models — infarct size reduction via CD36
GHSR-1a Selectivity
High-efficacy reference vs ipamorelin selective arm
GH Axis Desensitisation
Receptor downregulation kinetics with high-dose agonist
Quick Specs
| Form | Lyophilized powder — 5mg per vial, 10-vial kit |
| CAS Number | 140703-51-1 |
| Molecular Formula | C₄₇H₅₈N₁₂O₆ |
| Molecular Weight | 887.1 g/mol |
| Compound Type | GHSR-1a Agonist |
| Purity | ≥99% by HPLC — every batch |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house Fmoc SPPS — Qingdao, China |
| Storage | -20°C sealed | 2–8°C reconstituted (2–4 weeks) |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this Vesta compound and how is it verified?
All Vesta compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU · UK · USA · AU · Canada 5–7 days
International shipping: 7–14 days