For in vitro laboratory research only. Not for human or veterinary consumption.
4-Region Domestic Shipping Vesta Cagrilintide (Long-acting amylin receptor agonist) — ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only. Domestic shipping: EU · USA · AU · Canada 5–7 days International shipping: 7–14 days
Cagrilintide (Long-acting amylin receptor agonist (CALCR/RAMP)) is a Amylin analog (fatty acid-conjugated for weekly dosing). Long-acting amylin analog activating the amylin receptor complex (calcitonin receptor CALCR + receptor activity-modifying proteins RAMP1/2/3) via brainstem area postrema and hypothalamic circuits — appetite suppression pathway distinct from GLP-1R. Weekly dosing; combined with semaglutide in CagriSema Phase 3.
Research Applications
CALCR/RAMP Pharmacology
Amylin receptor complex activation — area postrema and hypothalamus
Brainstem Appetite Circuit
Independent of GLP-1R — distinct neuronal appetite suppression
Long-Acting Amylin PK
Weekly fatty acid-conjugated amylin analog pharmacokinetics
CagriSema Reference
Phase 3 component — isolated activity vs combination
vs Pramlintide
Short-acting (pramlintide) vs long-acting (cagrilintide) amylin research
Add 1–2mL bacteriostatic water to the lyophilized vial slowly, directing liquid down the wall. Swirl gently — do not shake. Cagrilintide is a fatty acid-modified amylin analogue and may take slightly longer to dissolve than short unmodified peptides.
How should Cagrilintide be stored?
Store lyophilized at −20°C. Reconstituted: 2–8°C for up to 28 days. Avoid freeze-thaw cycling of reconstituted solution. Store away from direct light.
What purity is Vesta Cagrilintide and how is it verified?
Vesta Cagrilintide is ≥99% pure by HPLC with MS-confirmed molecular identity on every batch. COA is published on the product page and independently verifiable at verify.janoshik.com.
Peptide Research Tools: Use Vesta’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
Domestic shipping: EU · USA · AU · Canada 5–7 days
International shipping: 7–14 days
Research use only
This material is supplied strictly for in vitro laboratory research. It is not intended for human or veterinary consumption, diagnosis, treatment, or household use.
