Short regulatory and thymic peptides
Epithalon
Epithalon (Epitalon) is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed on the basis of epithalamin, a polypeptide extract from the pineal gland.
- TypePeptide
- FormulaC14H22N4O9
- Average mass390.35 g/mol
- CAS307297-39-8
- Vesta listings2
Reference page for laboratory use · updated 2026-10-30
Overview
Epithalon at a glance
The peptide was developed by the Khavinson group in St. Petersburg. Early papers examine its effects in Drosophila, rodents and cultured cells, and a recent review summarises this literature.
Because the published work comes from a small number of laboratories, independent verification of the identity and purity of any supplied batch is especially important.
Structure
AEDG has four residues and no unusual modifications. The calculated formula and mass agree with the PubChem record.
Identity
Identity data
| Name | Epithalon |
|---|---|
| Also written as | Epitalon, Ala-Glu-Asp-Gly |
| Type | Peptide |
| Research area | Short regulatory and thymic peptides |
| Molecular formula | C14H22N4O9 |
| Monoisotopic mass | 390.1387 Da |
| Average molecular weight | 390.35 g/mol |
| CAS number | 307297-39-8, 64082-79-7 |
| Sequence | Ala-Glu-Asp-Gly |
| PubChem record | CID 219042 |
The formula was calculated independently from the written sequence and matches the PubChem record exactly. Reference data retrieved on 2026-10-30. Compare these values with the batch certificate of analysis, using the compound identity file template.
Expected values
Mass spectrometry reference
Ions calculated from the monoisotopic mass 390.1387 Da. Use them to check an LC-MS result; for larger peptides the instrument usually reports a deconvoluted mass close to 390.4 Da instead.
| Ion | m/z |
|---|---|
| [M+H]+ | 391.1460 |
| [M+Na]+ | 413.1279 |
| [M+K]+ | 429.1019 |
Read the guide to average and monoisotopic mass for how these values are calculated.
Quality
Analytical notes for batch documents
- Short, acidic peptides are very polar and may elute close to the solvent front on reversed-phase columns; check that the HPLC method retains the main peak.
- Counter-ion content is a large share of the powder mass for a peptide of 390 Da.
- No residue in this sequence is especially prone to oxidation or deamidation, so most extra peaks are likely to be synthesis-related impurities or adducts.
- The molecular weight of a vial of powder includes counter-ions and water; the share of the powder that is peptide is the net peptide content.
Terms used on this page: Peptide, HPLC, Counter-ion.
Vesta listings
Epithalon formats and prices
| Product | Per vial | SKU | Price per kit | Price per vial |
|---|---|---|---|---|
| Epithalon | 10 mg | ET10 | $63.43 | $6.34 |
| Epithalon | 50 mg | ET50 | $238.81 | $23.88 |
Prices are per kit of 10 vials in US dollars. Shipping is paid by the customer and is shown in the cart. Volume savings of 5 %, 8 % and 10 % apply from $350.00, $600.00 and $1,000.00. See the full price list.
Published literature
Selected scientific literature
Bibliographic details were read from PubMed on 2026-10-30. The papers are listed for scientific reference; Vesta makes no claim about the use of its research materials in people or animals.
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising PropertiesAraj SK, Brzezik J, Mądra-Gackowska K et al. · Int J Mol Sci · 2025 · PMID 40141333
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cellsKhavinson VKh, Bondarev IE, Butyugov AA et al. · Bull Exp Biol Med · 2003 · PMID 12937682
Questions
Frequently asked questions
What is Epithalon?
Epithalon (Epitalon) is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed on the basis of epithalamin, a polypeptide extract from the pineal gland.
What is the molecular weight of Epithalon?
Epithalon has the formula C14H22N4O9, an average molecular weight of 390.35 g/mol and a monoisotopic mass of 390.1387 Da. A salt form, a different counter-ion or a metal complex changes the molecular weight printed on a certificate of analysis, so compare like with like.
How can I check the identity of a batch of Epithalon?
Compare the intact mass measured by LC-MS with the expected values on this page, for example [M+Na]+ at m/z 413.1279. Confirm that one main HPLC peak carries that mass and that the batch code on the report matches the vial. The guides on mass spectrometry and on certificates of analysis explain each step.
Which Epithalon products does Vesta list?
Vesta lists 2 products for Epithalon: 10 mg, 50 mg per vial in kits of 10 vials. Prices are shown per kit in US dollars, and shipping is paid by the customer.